Photoshop CS6 running smoothly and bug-free on Ubuntu 10.04. Suddenly, all my qualms with not running windows are gone. I even got Zune Player to run without any hassles. Performance doesn't appear to be an issue.
The easiest way to do it is by installing Windows XP in VMWare Workstation (while allocating a fair amount of resources) and then running Photoshop CS6 in Unity (vmware) mode after installing vmware tools.
It works quite well. I'm running a barebones Windows XP VMWare in unity mode. With ubuntu and barebones xp, it runs just as quickly as it would on Windows 7 for me, so I don't see any problems with it. I basically allocated half of my ram and simulated 128mb of vram to the VM, and it works like a charm.